Characterization and application of the Fe(II) and α-ketoglutarate dependent hydroxylase FrbJ.
نویسندگان
چکیده
The Fe(II) and α-ketoglutarate-dependent hydroxylase FrbJ was previously demonstrated to utilize FR-900098 synthesizing a second phosphonate FR-33289. Here we assessed its ability to hydroxylate other possible substrates, generating a library of potential antimalarial compounds. Through a series of bioassays and in vitro experiments, we identified two new antimalarials.
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ورودعنوان ژورنال:
- Chemical communications
دوره 47 36 شماره
صفحات -
تاریخ انتشار 2011